The Highbrow Paleo Guide To Binge Drinking: Mitigating the deleterious effects of ethanol on health (or, How To Get Shitfaced With Impunity)

26 Dec

Part two can be found here http://highbrowpaleo.wordpress.com/2012/03/30/the-highbrow-paleo-guide-to-binge-drinking-addendum-further-discoveries-and-thanks-i-wuv-u-guys/ (seriously consider reading it, the percentage of people who read the second one is low and it is important)

Disclaimer: If you are a recovering alcoholic/recovering from a health issue or are a modern puritan, this blog post may not be suitable for you. In the case of 1. Good luck. In the case of 2. Get ye gone! I’m sure even reading this blog is sinful in some way. Are you still here? Get! Shoo!

“Paleo diet? But I like booze!”

Is this you on New Year's Eve?

And I like it too. Hi I’m Stabby and I love the sauce, but I also like to be healthy. It is sometimes assumed that these things are mutually exclusive, and that anything more than an ever so modest consumption of alcohol is a deal-breaker when it comes to our health. The notion that excessive drinking is damaging to health permeates the culture, and unlike some common beliefs about health, there is much truth to it. The list of maladies caused by excessive alcohol consumption is quite long, and excessive drinking is no laughing matter. However, some of us have social lives that may occasionally lead us into situations of being passed out on a bathroom floor with clever sharpie artistry augmenting the beauty of our visages. Shit happens, and that is the point of this blog post. In this post I’m not encouraging binge-drinking, just suggesting ways of ameliorating the damage when shit happens. Hot tub parties happen, and judgmental parents in law happen. Some of us have a love affair with booze that isn’t going to go away, but it is my belief that as long as we exercise a little bit of restraint and take some precautionary measures we can have our booze and drink it, too.

But the thing is that various nutritional interventions, particularly nutritional supplements, have a licensing effect on people leading them to feel invulnerable to unhealthy practices like smoking, eating junk food, and drinking, and they take a healthy practice as a license to do more of those unhealthy things. It is a tempting response to the promises of damage reduction, but no matter what we do, we will never completely eliminate alcohol’s effects. “I’m 50% protected against the ill-effects of alcohol, so I can drink 50% more!” is bad reasoning, and it is easy to succumb to it. We want to make drinking less damaging, but we don’t want to use that as a reason to be reckless. Just because you have a helmet doesn’t mean you should run into a wall.

Whew, okay then. I really hate moralizing, so that’s the last of it you’ll hear from me!

Apparently this blog is called Highbrow Paleo, so I’m going to quickly address the Paleotude of alcohol. Our gut flora produce a small amount of ethanol, about 3g, every day. So it isn’t like ethanol is this completely foreign substance that we don’t know how to handle like synthetic trans fats; far from it. Drinking alcohol provides a lot more alcohol than we would have seen during the bulk of evolution, but if the metabolic pathways exist already then there isn’t as much reason to think that alcohol is something that we can’t metabolize. There is definite reason to think that it is problematic, but the degree to which it is depends upon the body’s response to it, and that’s what I intend to investigate in this post. Alcohol doesn’t belong in the same category as trans fats, and while it has been tied to many diseases it is my belief that a generally unhealthy lifestyle deficient in nourishment and high in unhealthy foods, combined with a lifestyle that is at odds with our biology, is the driving factor that determines alcohol’s toxicity. It is still toxic no matter what, but less toxic when we hack our biology with nutrition and other tools. This is a guide on how to do so.

Too much ethanol is toxic, but why? There are many reasons, but the main reason cited has to do with its metabolism inside the liver. Ethanol is metabolized to acetaldehyde, and then hopefully to acetate, because acetaldehyde  is very toxic; it is highly reactive and is the main reason why alcohol produces liver damage. When metabolism of acetaldehyde is sluggish, meaning that the aldehyde dehydrogenase enzyme is downregulated, it is a very slow conversion and we see acetaldehyde accumulate all over the place. In the liver of course, in the blood, the heart, and the brain. We all know that feeling and it isn’t a pleasant one. We want to reduce the amount of acetaldehyde that gets produced, and detoxify the acetaldahyde that does get produced while preventing the damage it does while it’s on the loose. Our bodies are well equipped to do this, but if they aren’t properly nourished or if the immune system is sloppy and sluggish, then repairs will turn into demolition and we won’t be built up again but torn down.

So we need to upregulate the aldahyde dehydrogenase enzyme first and foremost. This will clean up acetaldehyde and reduce the toxicity of alcohol by converting it into a more benign molecule. By far the most effective way I know how to do it is to take pantethine. Pantethine is the precursor of coenzyme A, which is needed for various metabolic conversions. One of them is the Acetaldehyde –> Acetate –> Acetyl CoA pathway, and its effects on reducing acetaldehyde in the blood are quite pronounced (1). Unfortunately, it is only effective in some people; for those who have significant facial flushing from alcohol consumption, pantethine won’t do much to reduce acetaldehyde after drinking. But for everyone else it is excellent for reducing the toxic acetaldehyde load. Those who get very flushy are out of luck here, and aren’t the best candidates to be drinking to the extreme in the first place, but then again there is much that can be done to make drinking healthier for these people, which takes us to the heart of the topic.

Even if we can find biohacks to reduce the amount of acetaldehyde we have to deal with, we can’t eliminate its production entirely, so we must protect against it and detoxify it. The best way to do this is by supporting the body’s natural defenses, the sulfur-containing antioxidant enzymes, namely glutathione, one of our best antioxidants and detoxifiers which works in tandem with the rest of our antioxidant team.

Much of the work in the field of alcohol research is done in rodents, because apparently it is unethical to try to kill people with booze. The evidence that can be garnered from rat studies isn’t a perfect reflection of what would happen in humans, but it can give us good grounds to experiment for ourselves, and usually the mechanisms are  the same in humans and rats and I’m confident that supporting the same defenses in humans will produce the same results in the major aspects discussed.

The format of these studies usually goes something like this: A big mean scary scientist guy tries to kill some rats with toxic doses of booze, oh sure it’s fun at first and every rat gets lucky, but sooner or later the alcohol takes its toll and the rats in the control group get diseases. The rats in the intervention group get the protective nutrients, and we compare the difference in health between them. Science, bitchez, it, like, works!

Significant improvements in health after alcohol feeding have been seen with basic combinations of nutrients that you can get at a supplement store. The scientists in reference (2) had this to say in their summary:

“Greatest protection against anesthesia and lethality was obtained at 2 mM/kg with each of the following:l-cysteine N-acetyl-l-cysteine, thiamin HCl, sodium metabisulfite, andl-cysteic acid. A combination of l-ascorbic acid with l-cysteine, and thiamin·HCl at reduced dose levels (2.0, 1.0 and 0.3 mM/kg, respectively) gave virtually complete protection.”

Lucky rats, take that Mr. Reaper! L-cystine and n-acetyl-l-cysteine are precursors to glutathione, and ascorbic acid (Vitamin C) is important for glutathione’s redox. Thiamin, vitamin B1, appears to be important in protecting against acetaldehyde toxicity, and is greatly reduced by consumption of large amounts of alcohol. Sulfur (MSM in supplement form) improves glutathione status as well, acting as a rate-limiting factor for its synthesis from amino acids. We want to be supporting the synthesis of glutathione and our other antioxidant enzymes daily with a healthy diet and reasonable supplementation. But if we’re drinking frequently,  supplementation is going to be a boon. Physical activity prior to drinking is also very protective as it increases production of antioxidant enzymes and protects against ethanol toxicity in the liver and the brain. (3) (4) (5)

The active component of milk thistle, silymarin, has a pronounced protective effect on the liver when it is under stress from alcohol. It too works to preserve the health of the liver and its antioxidant enzymes (6), so do consider it.

Alcohol is intimately tied to another aspect of the cirrhosis spectrum diseases called fatty liver disease. Some of you may have heard about non-alcoholic fatty liver disease, which some believe sugar to play a role in. It is by far the less fun fatty liver disease to give yourself. The gist of it is that fat accumulates in the liver (steatosis) where it impairs its functioning, the liver becomes inflamed (steatohepatitis) as all of the damage needs to be repaired, but the dysfunctional immune system ends up being the nail in the coffin of the liver. There is fibrosis, an abnormal growth of  fibrous connective tissue, and our liver becomes very insulin resistant, creating problems elsewhere.  If we’re going to be abusing our livers, we should at least be sure that our immune system is on our side and we are doing everything we can to control inflammation. We’re degenerates, not imbeciles, thank you very much!

Possibly the biggest part of that is avoiding excessive amounts of omega-6 fatty acids, particularly the ones that have been oxidized and come from seed oils. Mice fed a diet high in omega-6 fatty acids develop the final stage of non-alcoholic fatty liver disease (and were lucky to not get any alcohol or it would have been worse) but conversely, when they are fed coconut oil or other saturated fatty acids it is actually protective due to the generation of adiponectin, a protective hormone that prevents insulin resistance and is a powerful anti-inflammatory signaler (7) (8). Adiponectin is lower in people with a lot of visceral fat, people eating low fat diets, low fiber intake, low activity level,  excessive inflammation, and other generally unhealthy practices (9) (10). But I’m assuming  that you’re health-conscious, probably following the paleo diet, and don’t need to be told to do any of these things. Regardless, you absolutely can’t be low in choline or your liver won’t be able to metabolize fat (11), so eat your eggs or else! Keeping the liver in good shape allows it to deal with a toxic load when it happens.

The list of maladies associated with excessive consumption of alcohol also includes brain damage and damage to the mucosal barrier of the gut, leading to a permeable or “leaky” gut. Reducing and detoxifying acetaldahyde will play a big role in preventing this, but we also want to enhance cellular defenses as much as we can. We already touched on glutathione, and it has also been found that polyphenols in strawberries protect the mucosa through stimulating production of defenses (12), and zinc has also been shown to be protective (13) (14). Various amino acids like glycine and glutamine will help to repair the mucosa, as well as Vitamin A. Carnosine, found in red meat, is an excellent protector of the brain (15) As are all sorts of berries. These things are all prevalent in the paleo diet for most, but it may be wise to ensure an especially high intake around the time of drinking or afterwards. Bone broth and gelatin have significant amounts of glycine, glutamine, and arginine which protect the gut and liver from alcohol as well (16) (17). It would be a great next-morning breakfast along with coffee or tea.

There are many nutrients that can curtail the inflammatory cascade that occurs when the liver is damaged, and while the paleo diet is generally strongly anti-inflammatory, extra ammunition will help nearly anyone. Ginger tea, quercetin, curcumin, resveratrol, and various herbs and spices protect the liver against ethanol toxicity and are helpful prior to or after a night of drinking (10) (18) (19) (20) (21). Red wine and quercetin are apparently a match made in heaven as red wine facilitates the absorption of quercetin (22). Score one more for booze! How’s that for healthy pills in your drink? Bound to confuse somebody, but not you.

Of course we want to stress moderation if possible, but if you find yourself just a little too drunk, consuming sugar will eliminate the alcohol from your blood faster (23). I recommend fresh fruit, which also has other protective elements.

Summary

Prior to drinking

  • Exercise
  • Pantethine
  • Glutathione-supporting nutrients: n-acetyl cysteine 500mg, alpha-lipoic acid, 500mg, MSM powder or comparable amount of sulfur from food – 5g
  • Thiamin 100mg
  • Choline 500mg
  • Carnosine 500mg
  • Milk thistle 500mg
  • All kinds of spices
  • Berries
  • Gelatin
  • Vitamin E (gamma tocepherol and tocetrienols, not just alpha-tocepherol and definitely not the synthetic form)

During or just before drinking

  • Curcumin 500mg
  • Quercetin 500mg
  • Ginger tea
  • Resveratrol 200-500mg
  • Anything else that is anti-inflammatory
  • Vitamin C
  • Vitamin E

The next day

  • Tea including ginger tea
  • Coffee
  • Gelatin/bone broth
  • All other nutrients that were consumed prior to drinking, because they will be low

This isn’t an exhaustive presentation of ways to protect yourself from alcohol’s ill-effects, and everyone should search further to find more remedies that work. There are other mechanisms that I haven’t touched upon, but the tips and tricks proposed within this article are likely to be protective in other ways that weren’t mentioned. If you have a particularly good remedy please share it, and have a happy holiday season, hopefully you will remember it! Cheers.

jager

References

1.   http://www.ncbi.nlm.nih.gov/pubmed/3893199

2.   http://www.springerlink.com/content/g414523058x71604/

3. http://www.ncbi.nlm.nih.gov/pubmed/18551810

4. http://www.ncbi.nlm.nih.gov/pubmed/20028365

5. http://www.ncbi.nlm.nih.gov/pubmed/20705416

6. http://www.ncbi.nlm.nih.gov/pubmed/17133738

7. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1398076/?tool=pubmed

8. http://perfecthealthdiet.com/?p=509

9.http://www.wellnessresources.com/studies/the_influence_of_fiber_fish_oil_and_exercise_on_adiponectin_levels

10.http://www.wellnessresources.com/studies/resveratrol_supports_adiponectin_by_reducing_inflammation/

11. http://www.ncbi.nlm.nih.gov/pubmed/11531217

12.http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025878

13. http://www.wellnessresources.com/studies/zinc_and_liver_damage

14.http://www.wellnessresources.com/studies/zinc_protects_against_alcohol_induced_intestinal_damage/

15. http://www.springerlink.com/content/e5478341649ul9rj/

16. http://www.ncbi.nlm.nih.gov/pubmed/15027101

17. http://jpet.aspetjournals.org/content/299/3/832.full

18. http://www.ncbi.nlm.nih.gov/pubmed/20599394

19. http://www.ncbi.nlm.nih.gov/pubmed/20383223

20. http://ajpgi.physiology.org/content/284/2/G321.long

21. http://www.ncbi.nlm.nih.gov/pubmed/20668581

22.http://www.wellnessresources.com/studies/resveratrol_supports_adiponectin_by_reducing_inflammation/

23. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1760706/?tool=pubmed

24. http://www.ajcn.org/content/28/3/254.full.pdf

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72 Responses to “The Highbrow Paleo Guide To Binge Drinking: Mitigating the deleterious effects of ethanol on health (or, How To Get Shitfaced With Impunity)”

  1. Aravind December 26, 2011 at 8:13 pm #

    Wow, I did not realize that raccoons were so versed in biochemistry and also had a penchant for libations. Seriously, I love the fact that this is such a well referenced post. Well stabbed!

    1) So do you actually employ the full arsenal of suggestions you’ve listed each time you drink or have you found a few of the things in particular provide enough bang for the buck…unless you are drinking enough to kill a small farm animal?

    2) Have you done any “controlled” tests to see your n=1 hangover with and without the supplementation? If so, any anecdotes you can share?

    Thanks,
    Aravind

    • Meredith December 26, 2011 at 8:43 pm #

      Raccoons love to PARTY!

    • Stabby December 27, 2011 at 1:56 am #

      I do many but not all. Sometimes it’s redundant like taking two powerful anti-inflammatories at once.

      I have never done anything scientific, but I have my anecdotes which say that this stuff works, as long as I don’t fall down and hit my head or get into the baked goods…

  2. A Slim Winter December 26, 2011 at 11:08 pm #

    Hi Stabbie!
    I’m wondering why anecdotally people believe that consuming sugary drinks (anything with sour mix, girl scout cookie inspired martinis, anything with godiva chocolate liqueur) gives them a worse hangover, when you say that consuming sugar helps the body rid itself of etoh faster? this is such an awesome post, i want to make out with it! but that might be the booze talking. thank you!!

    • Stabby December 27, 2011 at 1:54 am #

      They feel that because the sugar puts more stress on their liver and brain. I say that because it does clear alcohol faster and make them lesser drunk, but acetaldehyde is more toxic than ethanol itself. Sugar reduces ethanol but increased acetaldehyde. So that’s why I recommend fresh fruit, it’s not toxic like a pepsi.

  3. Mallory December 27, 2011 at 12:01 pm #

    NOW liver detox…
    Calories 10
    Total Carbohydrate 1 g <1%*
    Dietary Fiber 0.7 g 3%*
    Vitamin C (from Ascorbyl Palmitate) 12 mg 20%
    Milk Thistle (Standardized Extract) (Seeds)
    (Silybum marianum) (min. 80% Silymarin) 300 mg †
    Proprietary Herbal-Nutrient Blend
    Artichoke (Cynara scolymus) (Leaf), Beet (Beta vulgaris) (Leaf), Black Radish (Raphanus sativus) (Root), Bladderwrack (Fucus versiculosus) (Whole Plant),Raspberry (Rubus idaeus) (Leaf), Phosphatidyl Choline, Pancreatin (Pancreatic Enzymes), Blue Flag (Iris versicolor) (Root), Cleavers (Galium aparine) (Aerial Parts 250 mg †
    L-Glutathione (Free-Form) (Reduced) 100 mg †
    N-Acetyl Cysteine (NAC) 100 mg †
    Bupleurum (4:1 Conc. Extract) (Root) (Bupleurum chinense) 100 mg †
    Grape Seed (Standardized Extract) (Vitis vinefera) (min. 90% Polyphenols) 100 mg †
    Dandelion (4:1 Conc. Extract) (Root) (Taraxacum officinale) 100 mg †
    L-Carnitine Base 50 mg †
    Scute (4:1 Conc. Extract) (Root) (Sculellariae baicalensis) 50 mg †
    Pueraria (4:1 Conc. Extract) (Flower) (Pueraria thunbergiana) 50 mg †
    Schisandra (Fruit) (Schisandra chinensis) 50 mg †
    Barberry (Root Bark) (Berberis vulgaris) 30 mg †
    Turmeric (Root) (Curcuma longa) 30 mg †
    L-Methionine 20 mg †
    * Percent Daily Values are based on a 2,000 calorie diet.

  4. Jules December 27, 2011 at 12:12 pm #

    Just in time for New Year’s Eve, thanks Stabby! I look forward to my own n=1 this weekend.

    • August December 28, 2011 at 4:31 pm #

      Can verify ginger tea and gelatin is awesome mix.
      The NAC/Vitamin C combo works, but it seems a little dangerous to me. You can take this combo before every drink and make money drinking people under the table. But causing all those chemical reactions in your body just can’t be good.

  5. NBP December 28, 2011 at 6:54 pm #

    “Those who get very flushy are out of luck here, and aren’t the best candidates to be drinking to the extreme in the first place, but then again there is much that can be done to fix that.”

    What is the fix for this flush syndrome, whether it be caused by ALDH2 deficiency or otherwise? You suggest that B5 is not sufficient to prevent flush, and I wonder what can be done to prevent it.

    • highbrowpaleo January 1, 2012 at 2:18 am #

      I’m not entirely sure, because the enzyme deficiency is a huge piece in the puzzle, and has no immediate fix, I did say that these people aren’t the best candidates to be drinking large amounts. The best thing to give these people as much tolerance as possible would be to do everything to improve glutathione status, and especially make sure to be exercising the day of drinking, that tends to make all metabolic pathways work better, and increase glutathione in the body. Milk thistle, NAC, the vitamins, etc. Just so everything else as best you can and you should see improvements.

    • A Slim Winter January 1, 2012 at 10:34 pm #

      so, my mother has a acetaldehyde dehydrogenase deficiency (beats me; shes purely northern european) and she started taking a ranitidine (Zantac™), an H2 histamine receptor antagonist, before she drinks and it has fixed her issue with flushing. she doesn’t drink a lot, but it allows her to go out to dinner and have a glass of wine or two without looking like Barney™. she picked up that little trick from some asian college students who load up on antacids before hitting the bars.

      “Ranitidine reduces alcohol breakdown causing serum alcohol levels to increase substantially. Studies with rats have indicate that ranitidine, and to some degree other H2-receptor antagonists, impair alcohol dehydrogenase (ADH) activity when taken at therapeutic doses. Ranitidine also demonstrated either mixed or competitive inhibition of rat hepatic ADH. Thus, in alcoholics and in social drinkers who require treatment with H2-receptor antagonists, the prescribing physicians might choose to prescribe famotidine, instead of ranitidine or cimitidine, as a less problematic H2 blocker. Of course, stopping alcohol consumption represents a more direct route to eliminating this risk and would most likely also provide significant benefits in reducing the symptoms for which the ranitidine was originally prescribed. Even so, the levels of alcohol intake necessary to induce this interactions may be significantly higher than commonly consumed by most social drinkers on any consistent basis.
      (Caballeria J, et al. Dig Dis Sci 1991 Dec;36(12):1673-1679.)”

  6. Morgan December 28, 2011 at 7:04 pm #

    I’ve run across a fair number of epidemiological studies finding an association between coffee consumption and decreased risk of liver cirrhosis. Do you have any take on that:

    http://www.springerlink.com/content/x342322h01722p63/

    http://www.sciencedirect.com/science/article/pii/S104727970100223X

    Either way, I love me some Irish coffee.

    • Stabby December 28, 2011 at 7:19 pm #

      The anti-inflammatory and antioxidant effects it has will play a role. I’m sure there are other mechanisms. For those who are adverse to coffee there are many alternatives like the ones that I mentioned. But for those who do well with coffee and keep it to the AM and not too much, then it will probably be good for the liver

  7. primallykosher December 30, 2011 at 12:26 am #

    So does alcohol actually kill brain cells? I don’t think I would remember to take supplements after drinking vodka. I usually just sleep it off. I do like the idea of a egg breakfast though. Or an egg drop soup with a bone stock.

    • highbrowpaleo January 1, 2012 at 2:23 am #

      Yes it does, but it does a whole lot less if you take the supplements before drinking. While drinking may be a little better, especially with nutrients with a shot half-life in the body like vitamin c, but it’s not completely necessary. Using this stuff in the days leading up to the big night out drinking will probably help out too, we want to maintain the health of our livers for when shit happens, not just throw them a bone right before it happens. Although since you follow a primal diet you will be far more resistant to alcohol’s effects than most people. If you are the low carb variety of primal you may have more of a problem with it than the moderate carbers, that’s just my observation.

  8. Sean January 1, 2012 at 1:48 pm #

    Great article Stabby, keep it up!

  9. KKC January 1, 2012 at 6:50 pm #

    “We’re degenerates, not imbeciles, thank you very much!”

    LOL! Thank YOU very much, Stabby, both for the article and the line.

    Best,
    KKC

  10. Diana January 8, 2012 at 10:28 am #

    Stabby the Raccoon, can you write an article that will teach me how to read studies with all the Ps, Cs, metas, cohorts, relative risks, absolute risks, correlations and stuff ?

    While I really really really appreciate the bloggers simplifying it down for me, I would like to have some insight without having to retake my statistics course.

    Bacon and Butter,

    Diana

    • stabbyraccoon January 12, 2012 at 7:35 pm #

      Hey Diana, I’m pretty sure you could find someone better than me to explain it. I have a vague knowledge of this stuff but within Highbrow Paleo there are people who know more than I do. What I do is read read read and it falls into place. Wikipedia is helpful.

      But to be more useful to you, do what you can now and then buy Denise Minger’s new book that’s coming out, it will have a primer on that stuff and teach both of us a thing or two.

      Cheers.

  11. freemiss April 6, 2012 at 12:03 pm #

    Reblogged this on freemiss.

  12. SG April 12, 2012 at 5:01 pm #

    Hadn’t considered pantethine before.

    My experience of NACysteine (+ vit C) is that it definitely takes the edge off alcohol. Assumed that it helps break down acetaldehyde.

    But I saw this from Chris Masterjohn and wondered if NAC supplementation may be harmful:

    http://www.westonaprice.org/blogs/cmasterjohn/2012/04/07/glutathione-101-part-1-cysteine-misbehaves-but-glutathione-saves/

    • stabbyr April 13, 2012 at 8:50 pm #

      Thanks for the personal story!

      Chris makes a good point for why l-cystine might be a problem in some situations, and that is one of the reasons why I didn’t put l-cystine in the summary. I did mention it as a glutathione precursor, though. NAC just get turned into glutathione directly so I wouldn’t expect it to be a problem.

      • SG April 14, 2012 at 10:42 am #

        Thanks.

    • stabbyr April 23, 2012 at 1:57 am #

      On second thought, you may not want to take it all of the time. Take it before a particularly heavy drinking session but I was wrong, it CAN pose that problem. It may not always, particularly paired with pantethine, but there are many other ways of supporting glutathione levels all of the time.

      MSM, gelatin, whey, turmeric, green tea, etc, all will maintain good glutathine levels on a regular basis. NAC will act as heavy artillery when you need it most.

      • SG April 23, 2012 at 4:17 pm #

        Haven’t got my hands on pantethine yet – recommended dose?

        Tried beef liver and a raw egg last weekend, before drinking: seemed to take alot of the strength out of the alcohol ie. I was actually a bit bored by the end of the night!

      • stabbyr May 8, 2012 at 4:53 pm #

        Nice tip, maybe that’s because vitamin a protects the liver. A good pantethine dose is probably 300-900mg per day depending on what you want. I take one capsule with 450mg. Cheers.

  13. lindsay May 27, 2012 at 8:05 pm #

    My personal experience has been nothing short of a miracle with this protocol. It scares me a little actually.. I take 500mg NAC, 100mg ALA, 500mg Vit C, a Multi-Vit, 15 additional mg of Zinc, Turmeric, MSM if I remember, and Ginger. Then the next day I drink green tea, drink stock, drink lots of coffee… Seriously I don’t know what the hell is happening, but the other night I happened to accidentally drink in the neighborhood of 7 beers and 2 cocktails and felt like a first rate champion the next day. I had absolutely no sign of hangover or even a trace of alcohol detox. It was utterly amazing. I will say that I had tried the protocol whilst low carbing and it did not help nearly as much. After a week of a fairly high carb diet (for other reasons) it worked amazingly well. Like.. wow. Genius!

    Also, wondering if you have heard of the hangover drinks branded “Mercy”.. ? If not give them a quick google. They were apparently created by a neuroscientist and most of the ingredients are the things you recommend here.

    • stabbyr June 8, 2012 at 12:59 pm #

      That’s great news, thanks for your story! All of these reviews help other people with troubleshooting.

      I just looked at the Mercy product. Looks like they have the idea, some acetaldahyde dextox stuff, some electrolytes, some b vitamins, looks legit. I’m not crazy about supplemental b vitamins except for a few of them. So I wouldn’t use this product, because of the folic acid (not a good form of folate). And it’s expensive. Expensive supplements certainly work, but I think that people could get better results for less money. It’s all about priorities. Maybe some people just want a 1-shot product that’s effective, I can understand that.

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Trackbacks/Pingbacks

  1. Cocktailing for the non-sugar-addled « Highbrow Paleo - December 30, 2011

    [...] new year calls you. Get those glutathione-supporting nutrients and that quercetin. Buy yourself a bottle of Campari and a shaker. Then enjoy the lovely [...]

  2. Perfect Health Diet » 2011 in Review: Top Posts - December 31, 2011

    [...] first let me give a shout out to Stabby Raccoon’s “Guide to Binge Drinking,” at the new group blog “Highbrow Paleo.” If you plan to drink alcohol on New Year’s Eve, [...]

  3. Weekly Round-up « Highbrow Paleo - January 1, 2012

    [...] New Year’s Eve several members implemented Stabby’s nutriceutical drinking protocol – with GREAT [...]

  4. Perfect Health Diet » Around the Web: Bears in the Woods Edition - January 16, 2012

    [...] mentioned Stabby Raccoon’s binge drinking protocol last week. I didn’t mention that Stabby is from Alberta, Canada; and that the closer you live to [...]

  5. Training and nutrition linkfest, vol. 1 « Blunt Object - January 19, 2012

    [...] The Highbrow Paleo guide to binge drinking: Mitigating the deleterious effects of alcohol (or, How T…  (Highbrow Paleo) [...]

  6. The long-awaited return of “Chelsea” | CrossFit NYC - January 25, 2012

    [...] 30-day PALEO CHALLENGE — Day 20 Deconstructed gyro salad / Crispy spiced chicken livers Trojan horses of chlorella “superfood” Fat + vinegar + cooked, but then cooled potato = Lower glycemic response to starch. Good lard, bad lard: What do you get when you cross a pig and a coconut? How to get sh*tfaced with impunity [...]

  7. CrossFit Hustle - January 26, 2012

    [...] How to get sh*tfaced with impunity [...]

  8. Monday jerks & squats | CrossFit NYC - January 30, 2012

    [...] Maple macadamia nut butter Good lard, bad lard: What do you get when you cross a pig and a coconut? How to get sh*tfaced with impunity Chicken & butternut squash pesto / Mexican hash egg [...]

  9. Vanguard | CrossFit Haven | Glenview, IL - February 1, 2012

    [...] The Highbrow Paleo Guide to Binge Drinking Bookmark on Delicious Digg this post Recommend on Facebook Buzz it up Share on Linkedin share via Reddit Share with Stumblers Tweet about it Buzz it up Subscribe to the comments on this post Bookmark in Browser This entry was posted on Wednesday, February 1st, 2012 at 4:43 am. You can leave a response, or trackback from your own site. [...]

  10. Derby City CrossFit | Louisville | Workout of the Day – Thursday 2/2/12 - February 2, 2012

    [...] of Ex-Vegetarians The Top 7 Musts for Training Success How to Think About CrossFit Mental Toughness How to Get Sh*tfaced with Impunity Guide to Finding Your (Training) Partner Reebok is taking CrossFit to new heights. 1,050 feet [...]

  11. Weekly Round Up « Highbrow Paleo - March 6, 2012

    [...]  Tickets are being purchased, rooms are being booked, and most importantly, Stabby’s binge drinking protocol is being implemented in preparation of the [...]

  12. The Highbrow Paleo Guide To Binge Drinking: Addendum, Further Discoveries, And Thanks (I wuv U guys) « Highbrow Paleo - March 30, 2012

    [...] has been a while since I wrote the Highbrow Paleo Guide To Binge Drinking and there has been an outpouring of positive reactions from many readers. People say that they have [...]

  13. Missing Link(s) | Primal Bodybuilding and Health - April 6, 2012

    [...] The Highbrow Paleo guide to binge drinking! (just in time for my weekend!) How to avoid a hangover and drink more booze! [...]

  14. Huffington post on Aging gracefully.... | Mark's Daily Apple Health and Fitness Forum page - April 17, 2012

    [...] only conditionally. It depends on what you do. Check out my articles on how to drink healthfully. The Highbrow Paleo Guide To Binge Drinking: Mitigating the deleterious effects of ethanol on health … Exercise for 30 minutes at a time? Why? That seems arbitrary. You can get the same benefit in 10 [...]

  15. Cocktail Hour: The Logger « The Domestic Man - May 24, 2012

    [...] Binge Drinking: Mitigating the Deleterious Effects of Ethanol on Health posts, which you can find here and [...]

  16. Enter rant, stage right « Blunt Object - August 16, 2012

    [...] lifting.  And if you do, why not join me in five or six too many beers?  If you know enough about alcohol metabolism you won’t fear getting lucking foaded… and it’s in a good cause, because fuck the [...]

  17. Dear Mark: Beef Suet, Lowered HR, Alcohol, and Long Easy Runs | Mark's Daily Apple - October 22, 2012

    [...] Paleo did a two part series on reducing alcohol toxicity that went into even more detail. Read part one and part two. One of the Worker Bees swears by his [...]

  18. Paleo. Hangover. Cure. « Recreation and Whimsy - December 30, 2012

    [...] Sources: Mark’s Daily Apple and Highbrow Paleo [...]

  19. Perfect Health Diet, 2012 edition: an in-depth review of an in-depth book...PART 1 OF 2 - PainDatabase - January 3, 2013

    [...] The Jaminets were in a unique position when they wrote this book. They had already written a pretty excellent first edition of this book, followed by two solid years of reader experiences and discussions on their blog. Consequently, PHD 2012 is littered with highly-relevant testimonies of Perfect Health Dieters. Maybe littered isn’t the right word, but I certainly found them helpful — especially as PHD practitioners seem sharper than the average nutrition enthusiast. If you’re active in the paleo blogosphere, you might even notice some familiar names such as Stabby the Raccoon. [...]

  20. Ask Kamal and Stabby: "Is My Vegan Diet Killing Me?" - PainDatabase - January 25, 2013

    [...] and science expert (who’s apparently also a raccoon). Stabby’s written a lot about the science of binge drinking and the science of preventing hangovers. Trust me, this will all make sense in [...]

  21. Paleo Slow Cooker Breakfast - March 11, 2013

    [...] commitment to yourself for a healthier and happier you.So what is the paleo diet All About? A good deal of diets that are on the market these days will restrict your intake of carbs others will limit [...]

  22. Heavy drinking tips - October 3, 2014

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    The Highbrow Paleo Guide To Binge Drinking: Mitigating the deleterious effects of ethanol on health (or, How To Get Shitfaced With Impunity) | Highbrow Paleo

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